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Title   일반적 요법으로 치료한 호즈킨병의 경과 ( Conventional Treatments in Patients with Hodgkin's Disease )
Publicationinfo   1999 Jan; 031(04): 821-830.
Key_word   Conventional treatments, Hodgkins disease, High-dose chemotherapy, Autologous stem cell transplantation
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Abstract   Purpose: We conducted this study to determine the efficacy of conventional treatments for patients with Hodgkin's disease and identify the patients who have poor prognosis and need high-dose chemotherapy and autologous stem cell transplantation. Materials and Methods: Between Jun. 1989 and Dec. 1997, 50 patients were enrolled and 39 patients were evaluable. Patients were treated with radiotherapy (5 patients) or combination chemotherapy (21 patients) or combined chemotherapy and radiotherapy (13 patients) according to their disease stage. Chemotherapy regimens were C-MOPP (cyclo- phosphamide, vincristine, procarbazine, and prednisone), MOPP (mechlorethamine, vin- cristine, procarbazine, and prednisone), ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), alternating C-MOPP/ABVD, and MOPP/ABV hybrid. Radiation therapy was performed when there was residual tumor after chemotherapy or bulky disease. The response to treatments was analyzed by clinical stage I-II and stage III-IV patients group, respectively. Results: The complete response rate was 76.9% for total patients, 83.3% for stage I-II patients, and 71.4% for stage III-IV patients. Of the 30 patients achieving complete response, four (13.3%) relapsed at 6, 12, 22, and 28 months after complete response, respectively. The median follow-up duration was 24 months. Nine patients died. Four patients died of Hodgkins disease. Three-year overall survival rate was 72.9% for total patients, 72.5% for stage I-II patients, and 70% for stage III-IV patients. Two-year disease- free survival rate was 77.6% for total patients, 79% for stage I-II stage patients, and 73.9% for stage III-IV patients. The prognostic factor analysis showed that performance status affected the disease-free survival rate. Conclusion: Conventional treatments in patients with Hodgkins disease showed results comparable to previous studies. But we were unable to identify the patients, who need high-dose chemotherapy and autologous stem cell transplantation, because of small number of study patients and short follow up duration.
저 자   박종범(Jong Beom Park),서철원(Chul Won Seo),김상희(Sang Hee Kim),이경노(Kyung No Lee),송헌호(Hun Ho Song),박순서(Soon Seo Park),김효정(Hyo Jung Kim),민영주(Yung Joo Min),박진희(Jin Hee Park),최성준(Sung Joon Choe),김정균(Jung Koon Kim),김태원(Tae Won Kim),장대영(Dae Yung Jang),이제환(Je Hwan Lee)